![]() The combined evidence on the effects of physical activity at different intensities, ranging from large health surveys in an unselected population ( e.g., HUNT, via clinical studies to cellular and molecular mechanisms in experimental models outlines an integrated perspective on how regular physical activity at different intensities may be used to prevent and reverse the negative health effects of physical inactivity. Do these factors matter for the outcome of exercise training in prevention, treatment, and rehabilitation of cardiovascular disease and other lifestyle-related disorders? The working hypothesis based on results of several of our recent studies is that aerobic interval training at a relatively high intensity can be used in experimental and clinical settings and that this type of training induces larger beneficial effects to the heart compared with exercise training at moderate or low intensity. ![]() In contrast, sports science has established that mode, frequency, duration, and intensity are essential for the extent of the effects of exercise training. ![]() In medicine, exercise is often considered a unitary intervention that benefits health, and it has been common to categorize exercise training as strength or endurance, and more common to apply a relatively moderate intensity of the two exercise forms, and physiological adaptations to exercise at relatively high intensities have been less studied. ![]()
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